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Intravenous or intramuscular injections in hypotensive individuals or People in shock ought to be administered very carefully and crucial indicators needs to be monitored.[fifty eight]
Sternbach's process commenced with 2-amino-five-chlorobenzophenone, which undergoes cyclocondensation with glycine ethyl ester hydrochloride to assemble the benzodiazepine core. This Main is subsequently alkylated within the nitrogen inside the 1-position employing dimethyl sulfate from the existence of sodium methoxide and methanol underneath reflux ailments.
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